Global DNA Hypomethylation Prevents Consolidation of Differentiation Programs and Allows Reversion to the Embryonic Stem Cell State

DNA methylation patterns change dynamically during mammalian development and lineage specification, yet scarce information is available about how DNA methylation affects gene expression profiles upon differentiation. Here we determine genome-wide transcription profiles during undirected differentiat...

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Hauptverfasser: Schmidt, Christine S., Bultmann, Sebastian, Meilinger, Daniela, Zacher, Benedikt, Tresch, Achim, Maier, Kerstin C., Peter, Christian, Martin, Dietmar E., Leonhardt, Heinrich, Spada, Fabio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531338/
https://ncbi.nlm.nih.gov/pubmed/23300728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052629
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