Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers

Specific control of gene activity is a valuable tool to study and engineer cellular functions. Recent studies uncovered the potential of transcription activator-like effector (TALE) proteins that can be tailored to activate user-defined target genes. It remains however unclear whether and how epigen...

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Bibliographic Details
Main Authors: Bultmann, Sebastian, Morbitzer, Robert, Schmidt, Christine S., Thanisch, Katharina, Spada, Fabio, Elsaesser, Janett, Lahaye, Thomas, Leonhardt, Heinrich
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384321/
https://ncbi.nlm.nih.gov/pubmed/22387464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks199
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