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Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors
Screening efforts led to the identification of PI-8182 (1), an inhibitor of the chymotrypsin-like (CT-L) activity of the proteasome. Compound 1 contains a hydronaphthoquinone pharmacophore with a thioglycolic acid side chain at position 2 and thiophene sulfonamide at position 4. An efficient synthet...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3530929/ https://ncbi.nlm.nih.gov/pubmed/22220566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201118h |
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