Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase

BACKGROUND: Bacterial resistance to antibiotic therapies is increasing and new treatment options are badly needed. There is an overlap between these resistant bacteria and organisms classified as likely bioterror weapons. For example, Bacillus anthracis is innately resistant to the anti-folate trime...

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Huvudupphovsmän: Bourne, Christina R., Wakeham, Nancy, Nammalwar, Baskar, Tseitin, Vladimir, Bourne, Philip C., Barrow, Esther W., Mylvaganam, Shankari, Ramnarayan, Kal, Bunce, Richard A., Berlin, K. Darrell, Barrow, William W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530638/
https://ncbi.nlm.nih.gov/pubmed/22999981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2012.09.001
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