C-Terminal Helical Domains of Dengue Virus Type 4 E Protein Affect the Expression/Stability of prM Protein and Conformation of prM and E Proteins

BACKGROUND: The envelope (E) protein of dengue virus (DENV) is the major immunogen for dengue vaccine development. At the C-terminus are two α-helices (EH1 and EH2) and two transmembrane domains (ET1 and ET2). After synthesis, E protein forms a heterodimer with the precursor membrane (prM) protein,...

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Bibliographische Detailangaben
Hauptverfasser: Tsai, Wen-Yang, Hsieh, Szu-Chia, Lai, Chih-Yun, Lin, Hong-En, Nerurkar, Vivek R., Wang, Wei-Kung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530441/
https://ncbi.nlm.nih.gov/pubmed/23300717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052600
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