Characterization of the Ectodomain of the Envelope Protein of Dengue Virus Type 4: Expression, Membrane Association, Secretion and Particle Formation in the Absence of Precursor Membrane Protein

BACKGROUND: The envelope (E) of dengue virus (DENV) is the major target of neutralizing antibodies and vaccine development. After biosynthesis E protein forms a heterodimer with precursor membrane (prM) protein. Recent reports of infection enhancement by anti-prM monoclonal antibodies (mAbs) suggest...

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Hlavní autoři: Hsieh, Szu-Chia, Tsai, Wen-Yang, Nerurkar, Vivek R., Wang, Wei-Kung
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065094/
https://ncbi.nlm.nih.gov/pubmed/24950216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100641
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