The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation

BACKGROUND: Amino acid substitutions I22V and L72S in the prM protein of West Nile virus Kunjin strain (WNV(KUN)) were previously shown to enhance virus secretion and virulence, but a mechanism by which this occurred was not determined. FINDINGS: Using pulse-chase experiments followed by co-immunopr...

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Bibliografiske detaljer
Udgivet i:Virol J
Main Authors: Setoh, Yin Xiang, Tan, Cindy Si En, Prow, Natalie A, Hobson-Peters, Jody, Young, Paul R, Khromykh, Alexander A, Hall, Roy A
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Short Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4424586/
https://ncbi.nlm.nih.gov/pubmed/25946997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-015-0303-7
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