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An efficient sequential design of clinical trials
We propose an efficient group sequential monitoring rule for clinical trials. At each interim analysis both efficacy and futility are evaluated through a specified loss structure together with the predicted power. The proposed design is robust to a wide range of priors, and achieves the specified po...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3530214/ https://ncbi.nlm.nih.gov/pubmed/23275685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jspi.2012.07.015 |
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