Oestrogen treatment of experimental autoimmune encephalomyelitis requires 17β-oestradiol-receptor-positive B cells that up-regulate PD-1 on CD4(+) Foxp3(+) regulatory T cells

It is now well accepted that sex hormones have immunoregulatory activity and may prevent exacerbations in multiple sclerosis during pregnancy. Our previous studies demonstrated that oestrogen (17β-oestradiol; E(2)) protection against experimental autoimmune encephalomyelitis (EAE) is mediated mainly...

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Autores principales: Bodhankar, Sheetal, Vandenbark, Arthur A, Offner, Halina
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2012
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530084/
https://ncbi.nlm.nih.gov/pubmed/23039230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12013
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