A glutamate switch controls voltage-sensitive phosphatase function

Ciona intestinalis voltage sensing phosphatase Ci-VSP couples a voltage-sensing domain (VSD) to a lipid phosphatase similar to the tumor suppressor PTEN. How the VSD controls enzyme function has been unclear. Here, we present high-resolution crystal structures of the Ci-VSP enzymatic domain that rev...

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Autores principales: Liu, Lijun, Kohout, Susy C., Xu, Qiang, Müller, Simone, Kimberlin, Christopher R., Isacoff, Ehud Y., Minor, Daniel L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529583/
https://ncbi.nlm.nih.gov/pubmed/22562138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2289
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