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A glutamate switch controls voltage-sensitive phosphatase function
Ciona intestinalis voltage sensing phosphatase Ci-VSP couples a voltage-sensing domain (VSD) to a lipid phosphatase similar to the tumor suppressor PTEN. How the VSD controls enzyme function has been unclear. Here, we present high-resolution crystal structures of the Ci-VSP enzymatic domain that rev...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3529583/ https://ncbi.nlm.nih.gov/pubmed/22562138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2289 |
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