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Allosteric substrate switching in a voltage sensing lipid phosphatase
Allostery provides a critical control over enzyme activity, biasing the catalytic site between inactive and active states. We find the Ciona intestinalis voltage-sensing phosphatase (Ci-VSP), which modifies phosphoinositide signaling lipids (PIPs), to have not one but two sequential active states wi...
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| Publicado no: | Nat Chem Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4798927/ https://ncbi.nlm.nih.gov/pubmed/26878552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2022 |
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