TLR Signaling Prevents Hyperoxia-Induced Lung Injury by Protecting the Alveolar Epithelium from Oxidant-Mediated Death

Mechanical ventilation using high oxygen tensions is often necessary to treat patients with respiratory failure. Recently, TLRs were identified as regulators of noninfectious oxidative lung injury. IRAK-M is an inhibitor of MyD88-dependent TLR signaling. Exposure of mice deficient in IRAK-M (IRAK-M(...

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Detalhes bibliográficos
Main Authors: Ballinger, Megan N., Newstead, Michael W., Zeng, Xianying, Bhan, Urvashi, Horowitz, Jeffrey C., Moore, Bethany B., Pinsky, David J., Flavell, Richard A., Standiford, Theodore J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529412/
https://ncbi.nlm.nih.gov/pubmed/22661086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1103124
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