PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury

Fibrotic disorders of the lung are associated with perturbations in the plasminogen activation system. Specifically, plasminogen activator inhibitor-1 (PAI-1) expression is increased relative to the plasminogen activators. A direct role for this imbalance in modulating the severity of lung scarring...

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Autors principals: Osterholzer, John J, Christensen, Paul J, Lama, Vibha, Horowitz, Jeffrey C, Hattori, Noboru, Subbotina, Natalya, Cunningham, Andrew, Lin, Yujing, Murdock, Benjamin J, Morey, Roger E, Olszewski, Michal A, Lawrence, Daniel A, Simon, Richard H, Sisson, Thomas H
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529409/
https://ncbi.nlm.nih.gov/pubmed/22262246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.3992
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