Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers–Danlos syndrome

Zinc is essential but potentially toxic, so intracellular zinc levels are tightly controlled. A key strategy used by many organisms to buffer cytosolic zinc is to store it within vesicles and organelles. It is yet unknown whether vesicular or organellar sites perform this function in mammals. Human...

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Autores principales: Jeong, Jeeyon, Walker, Joel M., Wang, Fudi, Park, J. Genevieve, Palmer, Amy E., Giunta, Cecilia, Rohrbach, Marianne, Steinmann, Beat, Eide, David J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529093/
https://ncbi.nlm.nih.gov/pubmed/23213233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211775110
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