Use of covalently closed circular deoxyribonucleic acid for prescreening for antitumor compounds.

The interactions of PM-2 deoxyribonucleic acid (DNA) with 20 known antineoplastic agents were studied using agarose gel electrophoresis and fluorescence assay systems. Actinomycin D and adriamycin (and all other anthracyclines studied) induced superhelical conformational changes in PM-2 DNA. Bleomyc...

Celý popis

Podrobná bibliografie

Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Mong, S, Strong, J E, Bush, J A, Crooke, S T
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1979
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352867/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/507796/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.16.3.398
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!