Use of covalently closed circular deoxyribonucleic acid for prescreening for antitumor compounds.

The interactions of PM-2 deoxyribonucleic acid (DNA) with 20 known antineoplastic agents were studied using agarose gel electrophoresis and fluorescence assay systems. Actinomycin D and adriamycin (and all other anthracyclines studied) induced superhelical conformational changes in PM-2 DNA. Bleomyc...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Mong, S, Strong, J E, Bush, J A, Crooke, S T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1979
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352867/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/507796/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.16.3.398
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