Use of covalently closed circular deoxyribonucleic acid for prescreening for antitumor compounds.

The interactions of PM-2 deoxyribonucleic acid (DNA) with 20 known antineoplastic agents were studied using agarose gel electrophoresis and fluorescence assay systems. Actinomycin D and adriamycin (and all other anthracyclines studied) induced superhelical conformational changes in PM-2 DNA. Bleomyc...

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Bibliographic Details
Main Authors: Mong, S, Strong, J E, Bush, J A, Crooke, S T
Format: Artigo
Language:Inglês
Published: 1979
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC352867/
https://ncbi.nlm.nih.gov/pubmed/507796
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