Use of covalently closed circular deoxyribonucleic acid for prescreening for antitumor compounds.
The interactions of PM-2 deoxyribonucleic acid (DNA) with 20 known antineoplastic agents were studied using agarose gel electrophoresis and fluorescence assay systems. Actinomycin D and adriamycin (and all other anthracyclines studied) induced superhelical conformational changes in PM-2 DNA. Bleomyc...
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| 發表在: | Antimicrob Agents Chemother |
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| Principais autores: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology (ASM)
1979
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352867/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/507796/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.16.3.398 |
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