Structural features underlying T-cell receptor sensitivity to concealed MHC class I micropolymorphisms

Polymorphic differences distinguishing MHC class I subtypes often permit the presentation of shared epitopes in conformationally identical formats but can affect T-cell repertoire selection, differentially impacting autoimmune susceptibilities and viral clearance in vivo. The molecular mechanisms un...

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Autori principali: Stewart-Jones, Guillaume B., Simpson, Peter, Anton van der Merwe, P., Easterbrook, Philippa, McMichael, Andrew J., Rowland-Jones, Sarah L., Jones, E. Yvonne, Gillespie, Geraldine M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528510/
https://ncbi.nlm.nih.gov/pubmed/23161907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207896109
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