Conserved 33-kb haplotype in the MHC class III region regulates chronic arthritis

Genome-wide association studies have revealed many genetic loci associated with complex autoimmune diseases. In rheumatoid arthritis (RA), the MHC gene HLA-DRB1 is the strongest candidate predicting disease development. It has been suggested that other immune-regulating genes in the MHC contribute t...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Yau, Anthony C. Y., Tuncel, Jonatan, Haag, Sabrina, Norin, Ulrika, Houtman, Miranda, Padyukov, Leonid, Holmdahl, Rikard
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932949/
https://ncbi.nlm.nih.gov/pubmed/27303036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600567113
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