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Multiplicative fitness, rapid haplotype discovery, and fitness decay explain evolution of human MHC
The major histocompatibility complex (MHC) is a central component of the vertebrate immune system and hence evolves in the regime of a host–pathogen evolutionary race. The MHC is associated with quantitative traits which directly affect fitness and are subject to selection pressure. The evolution of...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6628782/ https://ncbi.nlm.nih.gov/pubmed/31227609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714436116 |
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