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HLA class I haplotype diversity is consistent with selection for frequent existing haplotypes
The major histocompatibility complex (MHC) contains the most polymorphic genetic system in humans, the human leukocyte antigen (HLA) genes of the adaptive immune system. High allelic diversity in HLA is argued to be maintained by balancing selection, such as negative frequency-dependent selection or...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5590998/ https://ncbi.nlm.nih.gov/pubmed/28846675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005693 |
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