Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice

Leukocyte chemotaxis is deemed instrumental in initiation and progression of atherosclerosis. It is mediated by G-protein-coupled receptors (e.g., CCR2 and CCR5), the activity of which is controlled by G-protein-coupled receptor kinases (GRKs). In this study, we analyzed the effect of hematopoietic...

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Main Authors: Otten, Jeroen J. T., de Jager, Saskia C. A., Kavelaars, Annemieke, Seijkens, Tom, Bot, Ilze, Wijnands, Erwin, Beckers, Linda, Westra, Marijke M., Bot, Martine, Busch, Matthias, Bermudez, Beatriz, van Berkel, Theo J. C., Heijnen, Cobi J., Biessen, Erik A. L.
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528319/
https://ncbi.nlm.nih.gov/pubmed/23047899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-205351
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