Inhibition by Ethambutol of Mycolic Acid Transfer into the Cell Wall of Mycobacterium smegmatis

Ethambutol simultaneously inhibited the transfer (presumably via mycolyl acetyl trehalose) of mycolic acids into the cell wall and stimulated the synthesis of trehalose dimycolates of Mycobacterium smegmatis. Structural similarities of the drug and mycolyl acetyl trehalose suggested that competitive...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Takayama, Kuni, Armstrong, Emma L., Kunugi, Keith A., Kilburn, James O.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1979
Soggetti:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352831/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/485133/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.16.2.240
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