Inhibition by Ethambutol of Mycolic Acid Transfer into the Cell Wall of Mycobacterium smegmatis

Ethambutol simultaneously inhibited the transfer (presumably via mycolyl acetyl trehalose) of mycolic acids into the cell wall and stimulated the synthesis of trehalose dimycolates of Mycobacterium smegmatis. Structural similarities of the drug and mycolyl acetyl trehalose suggested that competitive...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Takayama, Kuni, Armstrong, Emma L., Kunugi, Keith A., Kilburn, James O.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1979
Assuntos:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352831/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/485133/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.16.2.240
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