Inhibition by Ethambutol of Mycolic Acid Transfer into the Cell Wall of Mycobacterium smegmatis

Ethambutol simultaneously inhibited the transfer (presumably via mycolyl acetyl trehalose) of mycolic acids into the cell wall and stimulated the synthesis of trehalose dimycolates of Mycobacterium smegmatis. Structural similarities of the drug and mycolyl acetyl trehalose suggested that competitive...

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Detalles Bibliográficos

Publicado en:	Antimicrob Agents Chemother
Autores principales:	Takayama, Kuni, Armstrong, Emma L., Kunugi, Keith A., Kilburn, James O.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1979
Materias:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352831/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/485133/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.16.2.240
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