The Effects of Transmembrane Sequence and Dimerization on Cleavage of the p75 Neurotrophin Receptor by γ-Secretase

Cleavage of transmembrane receptors by γ-secretase is the final step in the process of regulated intramembrane proteolysis (RIP) and has a significant impact on receptor function. Although relatively little is known about the molecular mechanism of γ-secretase enzymatic activity, it is becoming clea...

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Bibliographic Details
Main Authors: Sykes, Alex M., Palstra, Nickless, Abankwa, Daniel, Hill, Justine M., Skeldal, Sune, Matusica, Dusan, Venkatraman, Prahatha, Hancock, John F., Coulson, Elizabeth J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527965/
https://ncbi.nlm.nih.gov/pubmed/23105112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.382903
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