p75 Neurotrophin Receptor Cleavage by α- and γ-Secretases Is Required for Neurotrophin-mediated Proliferation of Brain Tumor-initiating Cells

Malignant gliomas are highly invasive, proliferative, and resistant to treatment. Previously, we have shown that p75 neurotrophin receptor (p75NTR) is a novel mediator of invasion of human glioma cells. However, the role of p75NTR in glioma proliferation is unknown. Here we used brain tumor-initiati...

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Main Authors: Forsyth, Peter A., Krishna, Niveditha, Lawn, Samuel, Valadez, J. Gerardo, Qu, Xiaotao, Fenstermacher, David A., Fournier, Michelle, Potthast, Lisa, Chinnaiyan, Prakash, Gibney, Geoffrey T., Zeinieh, Michele, Barker, Philip A., Carter, Bruce D., Cooper, Michael K., Kenchappa, Rajappa S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961639/
https://ncbi.nlm.nih.gov/pubmed/24519935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.513762
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