p75 Neurotrophin Receptor Cleavage by α- and γ-Secretases Is Required for Neurotrophin-mediated Proliferation of Brain Tumor-initiating Cells

Malignant gliomas are highly invasive, proliferative, and resistant to treatment. Previously, we have shown that p75 neurotrophin receptor (p75NTR) is a novel mediator of invasion of human glioma cells. However, the role of p75NTR in glioma proliferation is unknown. Here we used brain tumor-initiati...

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Detalhes bibliográficos
Main Authors: Forsyth, Peter A., Krishna, Niveditha, Lawn, Samuel, Valadez, J. Gerardo, Qu, Xiaotao, Fenstermacher, David A., Fournier, Michelle, Potthast, Lisa, Chinnaiyan, Prakash, Gibney, Geoffrey T., Zeinieh, Michele, Barker, Philip A., Carter, Bruce D., Cooper, Michael K., Kenchappa, Rajappa S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961639/
https://ncbi.nlm.nih.gov/pubmed/24519935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.513762
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