Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor

The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP) of p75(NTR) is required for p75(NTR)-mediate...

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Main Authors: Wang, LiMei, Rahn, Jennifer J, Lun, XueQing, Sun, Beichen, Kelly, John J. P, Weiss, Samuel, Robbins, Stephen M, Forsyth, Peter A, Senger, Donna L
格式: Artigo
語言:Inglês
出版: Public Library of Science 2008
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586378/
https://ncbi.nlm.nih.gov/pubmed/19067488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060289
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