Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain

Inside-out activation of integrins is mediated via the binding of talin and kindlin to integrin β-subunit cytoplasmic tails. The kindlin FERM domain is interrupted by a pleckstrin homology (PH) domain within its F2 subdomain. Here, we present data confirming the importance of the kindlin-1 PH domain...

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Detalhes bibliográficos
Main Authors: Yates, Luke A., Lumb, Craig N., Brahme, Nina N., Zalyte, Ruta, Bird, Louise E., De Colibus, Luigi, Owens, Raymond J., Calderwood, David A., Sansom, Mark S. P., Gilbert, Robert J. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527912/
https://ncbi.nlm.nih.gov/pubmed/23132860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.422089
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