Upregulating Noxa by ER Stress, Celastrol Exerts Synergistic Anti-Cancer Activity in Combination with ABT-737 in Human Hepatocellular Carcinoma Cells

The human hepatocellular carcinoma (HCC) represents biologically aggressive and chemo-resistant cancers. Owing to the low affinity with the apoptotic factor Mcl-1, the BH3 mimetic drug ABT-737 failed to exert potent cancer-killing activities in variety of cancer models including HCC. The current stu...

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Detalhes bibliográficos
Main Authors: Zhu, Hong, Yang, Wei, He, Ling-juan, Ding, Wan-jing, Zheng, Lin, Liao, Si-da, Huang, Ping, Lu, Wei, He, Qiao-jun, Yang, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527540/
https://ncbi.nlm.nih.gov/pubmed/23284992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052333
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