A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers

BACKGROUND: SRT2104 has been developed as a selective small molecule activator of SIRT1, a NAD(+)-dependent deacetylase involved in the regulation of energy homeostasis and the modulation of various metabolic pathways, including glucose metabolism, oxidative stress and lipid metabolism. SIRT1 has be...

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Detalhes bibliográficos
Main Authors: Libri, Vincenzo, Brown, Andrew P., Gambarota, Giulio, Haddad, Jonathan, Shields, Gregory S., Dawes, Helen, Pinato, David J., Hoffman, Ethan, Elliot, Peter J., Vlasuk, George P., Jacobson, Eric, Wilkins, Martin R., Matthews, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527451/
https://ncbi.nlm.nih.gov/pubmed/23284689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051395
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