Phosphonopeptides as Antibacterial Agents: Rationale, Chemistry, and Structure-Activity Relationships

Peptide mimetics with C-terminal residues simulating natural amino acids have been designed as inhibitors of bacterial cell wall biosynthesis. The phosphonopeptide series consisting of various l and d residues of natural amino acids combined with 1-aminoalkyl (and aryl-alkyl-) phosphonic acid residu...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Atherton, Frank R., Hali, Michael J., Hassall, Cedric H., Lambert, Robert W., Ringrose, Peter S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1979
Subjects:
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352738/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/525986/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.15.5.677
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