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Polyethyleneimine-lipid conjugate-based pH-sensitive micellar carrier for gene delivery
A low molecular weight polyethyleneimine (PEI 1.8 kDa) was modified with dioleoylphosphatidylethanolamine (PE) to form the PEI-PE conjugate investigated as a transfection vector. The optimized PEI-PE/pDNA complexes at an N/P ratio of 16 had a particle size of 225 nm, a surface charge of +31 mV, and...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527089/ https://ncbi.nlm.nih.gov/pubmed/22365809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2011.11.088 |
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