Phospholipid-modified polyethylenimine-based nanopreparations for siRNA–mediated gene silencing: Implications for transfection and the role of lipid components

The clinical application of gene silencing mediated by small interfering RNA (siRNA) has been limited by the lack of efficient and safe carriers. Phospholipid modification of low molecular weight polyethylenimine (PEI 1.8 kDa) dramatically increased its gene down-regulation capacity while keeping cy...

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Main Authors: Navarro, Gemma, Essex, Sean, Sawant, Rupa R., Biswas, Swati, Nagesha, Dattatri, Sridhar, Srinivas, de ILarduya, Conchita Tros, Torchilin, Vladimir P.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916950/
https://ncbi.nlm.nih.gov/pubmed/23928214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2013.07.016
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