Rotenone Inhibits Autophagic Flux Prior to Inducing Cell Death

[Image: see text] Rotenone, which selectively inhibits mitochondrial complex I, induces oxidative stress, α-synuclein accumulation, and dopaminergic neuron death, principal pathological features of Parkinson's disease. The autophagy–lysosome pathway degrades damaged proteins and organelles for...

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Bibliographic Details
Main Authors: Mader, Burton J., Pivtoraiko, Violetta N., Flippo, Hilary M., Klocke, Barbara J., Roth, Kevin A., Mangieri, Leandra R., Shacka, John J.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2012
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526971/
https://ncbi.nlm.nih.gov/pubmed/23259041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300145z
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