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Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart
Klotho is a membrane protein predominantly produced in the kidney that exerts some anti-ageing effects. Ageing is associated with an increased risk of heart failure; whether Klotho is cardioprotective is unknown. Here we show that Klotho-deficient mice have no baseline cardiac abnormalities but deve...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3526952/ https://ncbi.nlm.nih.gov/pubmed/23212367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2240 |
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