Chloroquine Resistance in Malaria: Accessibility of Drug Receptors to Mefloquine

The process of mefloquine accumulation was studied in mouse erythrocytes infected with either Plasmodium berghei CS (chloroquine susceptible) or P. berghei CR (chloroquine resistant). In both cases, mefloquine was accumulated by a saturable process with an apparent dissociation constant of 2.5 × 10(...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Fitch, Coy D., Chan, Robert L., Chevli, Rekha
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1979
Schlagworte:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/371544/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.15.2.258
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