Chloroquine Resistance in Malaria: Accessibility of Drug Receptors to Mefloquine

The process of mefloquine accumulation was studied in mouse erythrocytes infected with either Plasmodium berghei CS (chloroquine susceptible) or P. berghei CR (chloroquine resistant). In both cases, mefloquine was accumulated by a saturable process with an apparent dissociation constant of 2.5 × 10(...

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Εκδόθηκε σε:	Antimicrob Agents Chemother
Κύριοι συγγραφείς:	Fitch, Coy D., Chan, Robert L., Chevli, Rekha
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	American Society for Microbiology (ASM) 1979
Θέματα:	Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC352643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/371544/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.15.2.258
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