Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

The CD3ε and ζ cytoplasmic domains of the T cell receptor bind to the inner leaflet of the plasma membrane (PM), and a previous nuclear magnetic resonance structure showed that both tyrosines of the CD3ε immunoreceptor tyrosine-based activation motif partition into the bilayer. Electrostatic interac...

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Hlavní autoři: Gagnon, Etienne, Schubert, David A., Gordo, Susana, Chu, H. Hamlet, Wucherpfennig, Kai W.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526357/
https://ncbi.nlm.nih.gov/pubmed/23166358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120790
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