Antisense morpholino targeting just upstream from a poly(A) tail junction of maternal mRNA removes the tail and inhibits translation

Gene downregulation by antisense morpholino oligonucleotides (MOs) is achieved by either hybridization around the translation initiation codon or by targeting the splice donor site. In the present study, an antisense MO method is introduced that uses a 25-mer MO against a region at least 40-nt upstr...

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Bibliographische Detailangaben
Hauptverfasser: Wada, Tadashi, Hara, Masatoshi, Taneda, Takuya, Qingfu, Cao, Takata, Ryouhei, Moro, Kanako, Takeda, Kei, Kishimoto, Takeo, Handa, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526265/
https://ncbi.nlm.nih.gov/pubmed/22904086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks765
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