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Antisense morpholino targeting just upstream from a poly(A) tail junction of maternal mRNA removes the tail and inhibits translation

Gene downregulation by antisense morpholino oligonucleotides (MOs) is achieved by either hybridization around the translation initiation codon or by targeting the splice donor site. In the present study, an antisense MO method is introduced that uses a 25-mer MO against a region at least 40-nt upstr...

תיאור מלא

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מידע ביבליוגרפי
Main Authors: Wada, Tadashi, Hara, Masatoshi, Taneda, Takuya, Qingfu, Cao, Takata, Ryouhei, Moro, Kanako, Takeda, Kei, Kishimoto, Takeo, Handa, Hiroshi
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526265/
https://ncbi.nlm.nih.gov/pubmed/22904086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks765
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