The ω3-polyunsaturated fatty acid derivatives AVX001 and AVX002 directly inhibit cytosolic phospholipase A(2) and suppress PGE(2) formation in mesangial cells

BACKGROUND AND PURPOSE: ω3-polyunsaturated fatty acids (ω3-PUFAs) are known to exert anti-inflammatory effects in various disease models although their direct targets are only poorly characterized. EXPERIMENTAL APPROACH: Here we report on two new cPLA(2) inhibitors, the ω3-derivatives AVX001 and AVX...

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Dettagli Bibliografici
Autori principali: Huwiler, Andrea, Feuerherm, Astrid J, Sakem, Benjamin, Pastukhov, Oleksandr, Filipenko, Iuliia, Nguyen, Thuy, Johansen, Berit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2012
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525871/
https://ncbi.nlm.nih.gov/pubmed/22831644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02114.x
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