Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat

BACKGROUND AND PURPOSE: The cannabinoid receptor-mediated analgesic effects of 2-arachidonoylglycerol (2-AG) are limited by monoacylglycerol lipase (MAGL). 4-nitrophenyl 4-[bis (1,3-benzodioxol-5-yl) (hydroxy) methyl] piperidine-1-carboxylate (JZL184) is a potent inhibitor of MAGL in the mouse, thou...

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Autores principales: Woodhams, SG, Wong, A, Barrett, DA, Bennett, AJ, Chapman, V, Alexander, SPH
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2012
Materias:
Themed Section: Research Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525864/
https://ncbi.nlm.nih.gov/pubmed/22924700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02179.x
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