Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients

PURPOSE: Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) is a promising treatment for metastatic melanoma unresponsive to conventional therapies. We report here on the results of an ongoing Phase II clinical trial testing the efficacy of ACT using TIL in metastatic...

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Główni autorzy: Radvanyi, Laszlo G., Bernatchez, Chantale, Zhang, Minying, Fox, Patricia S., Miller, Priscilla, Chacon, Jessica, Wu, Richard, Lizee, Gregory, Mahoney, Sandy, Alvarado, Gladys, Glass, Michelle, Johnson, Valen E., McMannis, John D., Shpall, Elizabeth, Prieto, Victor, Papadopoulos, Nicholas, Kim, Kevin, Homsi, Jade, Bedikian, Agop, Hwu, Wen-Jen, Patel, Sapna, Ross, Merrick I., Lee, Jeffrey E., Gershenwald, Jeffrey E., Lucci, Anthony, Royal, Richard, Cormier, Janice N., Davies, Michael A., Mansaray, Rahmatu, Fulbright, Orenthial J., Toth, Christopher, Ramachandran, Renjith, Wardell, Seth, Gonzalez, Audrey, Hwu, Patrick
Format: Artigo
Język:Inglês
Wydane: 2012
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525747/
https://ncbi.nlm.nih.gov/pubmed/23032743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1177
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