Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients

PURPOSE: Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) is a promising treatment for metastatic melanoma unresponsive to conventional therapies. We report here on the results of an ongoing Phase II clinical trial testing the efficacy of ACT using TIL in metastatic...

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Hauptverfasser: Radvanyi, Laszlo G., Bernatchez, Chantale, Zhang, Minying, Fox, Patricia S., Miller, Priscilla, Chacon, Jessica, Wu, Richard, Lizee, Gregory, Mahoney, Sandy, Alvarado, Gladys, Glass, Michelle, Johnson, Valen E., McMannis, John D., Shpall, Elizabeth, Prieto, Victor, Papadopoulos, Nicholas, Kim, Kevin, Homsi, Jade, Bedikian, Agop, Hwu, Wen-Jen, Patel, Sapna, Ross, Merrick I., Lee, Jeffrey E., Gershenwald, Jeffrey E., Lucci, Anthony, Royal, Richard, Cormier, Janice N., Davies, Michael A., Mansaray, Rahmatu, Fulbright, Orenthial J., Toth, Christopher, Ramachandran, Renjith, Wardell, Seth, Gonzalez, Audrey, Hwu, Patrick
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525747/
https://ncbi.nlm.nih.gov/pubmed/23032743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-1177
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