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Hypoxia-Selective DNA Interstrand Cross-Link Formation by Two Modified Nucleosides
Two nitroimidazole modified thymidines 1a and 1b have been synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1a and 1b generated a 5-(2′-deoxyuridinyl)methyl radical that induced DNA interstrand cross-links (ICL). Higher ICL yield was observed under hypoxic conditions than ae...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3525362/ https://ncbi.nlm.nih.gov/pubmed/22936396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201201960 |
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