Carregando...
Hypoxia-Selective DNA Interstrand Cross-Link Formation by Two Modified Nucleosides
Two nitroimidazole modified thymidines 1a and 1b have been synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1a and 1b generated a 5-(2′-deoxyuridinyl)methyl radical that induced DNA interstrand cross-links (ICL). Higher ICL yield was observed under hypoxic conditions than ae...
Na minha lista:
| Principais autores: | , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3525362/ https://ncbi.nlm.nih.gov/pubmed/22936396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201201960 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|