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Integrating Sequence Variation and Protein Structure to Identify Sites under Selection

We present a novel method to identify sites under selection in protein-coding genes. Our method combines the traditional Goldman–Yang model of coding-sequence evolution with the information obtained from the 3D structure of the evolving protein, specifically the relative solvent accessibility (RSA)...

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Detalhes bibliográficos
Main Authors: Meyer, Austin G., Wilke, Claus O.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525147/
https://ncbi.nlm.nih.gov/pubmed/22977116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mss217
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