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Translationally Optimal Codons Associate with Structurally Sensitive Sites in Proteins
The mistranslation-induced protein misfolding hypothesis predicts that selection should prefer high-fidelity codons at sites at which translation errors are structurally disruptive and lead to protein misfolding and aggregation. To test this hypothesis, we analyzed the relationship between codon usa...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734146/ https://ncbi.nlm.nih.gov/pubmed/19349643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msp070 |
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