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Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli
Tyrosine hydroxylase is the rate-limiting step in the synthesis of dopamine and is tightly regulated. Previous studies have shown it to be covalently modified and potently inhibited by 3,4-dihydroxyphenylacetaldehyde (DOPAL), an endogenous neurotoxin via dopamine catabolism which is relevant to Park...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3525113/ https://ncbi.nlm.nih.gov/pubmed/22659380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2012.05.007 |
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